Professor Southern joined the University of Liverpool and Alder Hey Children’s Hospital on the 1st January 2000.  He is Director of the Cheshire, Merseyside and North Wales Network of Paediatric Cystic Fibrosis Care, caring for over 300 children with CF in the North West of England.  He is the Chief Investigator on two national studies funded by the UK government.  CF START will evaluate the safest and most effective antibiotic treatment strategy for infants with CF and CF STORM will assess if people with CF, established on triple therapy, can safely stop nebulised muco-active therapies.  In 2007, he helped establish the UK Newborn Screening Programme for CF and he now chairs the national Board overseeing this programme. He was Leader of the European CF Society Neonatal Screening Working Group for more than ten years, handing over to Professor Jürg Barben in 2019.  He is an Editor for the international Cochrane Review Group evaluating evidence for therapies for people with CF.  In addition to his editorial role, he has written and contributed to 12 systematic reviews and his research is focused on translating evidence into practice.  He has published over 150 peer reviewed articles on cystic fibrosis and is internationally respected for his work on newborn screening.  He is the joint editor of a textbook sponsored by the European CF Society, the “Early CF Years”.  For seven years, he was an elected member of the ECFS Board and, as such, has a global perspective on the issues facing people with CF.  As Director of the ECFS Standards Committee, he has coordinated the production of five papers updating standards for the care of people with CF.